Your browser version may not work well with NCBI's Web applications. More information here...
1: Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31.Click here to read Links

Actinomycin and DNA transcription.

Sobell HM.

Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.

PMID: 2410919 [PubMed - indexed for MEDLINE]

PMCID: PMC390561

Patient Drug Information

  • Dactinomycin (Cosmegen® )

    Your doctor has ordered the drug dactinomycin to help treat your illness. The drug is given by injection into a vein.

  • Source: AHFS Consumer Medication Information

Recent Activity