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    Proc Natl Acad Sci U S A. 1985 Aug;82(16):5328-31.

    Actinomycin and DNA transcription.

    Sobell HM.

    Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.

    PMID: 2410919 [PubMed - indexed for MEDLINE]

    PMCID: PMC390561

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      Your doctor has ordered the drug dactinomycin to help treat your illness. The drug is given by injection into a vein.

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