The parametric amplification gain and bandwidth in highly nonlinear tellurite hybrid microstructured optical fiber (HMOF) are simulated based on four wave mixing process. The fiber core and cladding materials are made of TeO(2)–Li(2)O–WO(3)–MoO(3)–Nb(2)O(5) and TeO(2)–ZnO–Na(2)O–P(2)O(5) glass, respectively. The fiber has four zero-dispersion wavelengths and the chromatic dispersion is flattened near the zerodispersion wavelengths. A broad gain bandwidth as wide as 1200 nm from 1290 to 2490 nm can be realized in the near infrared window by using a tellurite HMOF as short as 25 cm.