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J Stroke Cerebrovasc Dis. 2014 May-Jun;23(5):1235-8. doi: 10.1016/j.jstrokecerebrovasdis.2013.07.031. Epub 2013 Oct 6.

Intravenous thrombolysis for ischemic stroke in recurrent oligodendroglioma: a case report.

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  • 1Department of Neurology, NorthShore University Health System, Evanston, Illinois; Department of Neurology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois. Electronic address:
  • 2Department of Neurology, Rush Medical Center, Chicago, Illinois.
  • 3Department of Neurology, NorthShore University Health System, Evanston, Illinois.


Data on efficacy and safety of intravenous (IV) thrombolysis with recombinant tissue plasminogen activator (rtPA) in patients with acute ischemic stroke (AIS) and intracranial neoplasm are lacking. To date, only a handful of case reports have been published in the literature addressing the administration of IV rtPA to patients with AIS and coexisting brain neoplasms. We present the case of successful IV thrombolysis with rtPA for AIS in a patient with oligodendroglioma on bevacizumab without hemorrhagic complications. We summarize the published cases of thrombolysis in AIS in patients with intracranial neoplasms.

Copyright © 2014 National Stroke Association. Published by Elsevier Inc. All rights reserved.


Thrombolysis; brain tumors; ischemic stroke; oligodendroglioma

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