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J Immunol. 2013 Oct 15;191(8):3973-9. doi: 10.4049/jimmunol.1301843.

TGF-β: guardian of T cell function.

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  • 1Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.


A fundamental aspect of the adaptive immune system is the generation and maintenance of a diverse and self-tolerant T cell repertoire. Through its regulation of T cell development, homeostasis, tolerance, and differentiation, the highly evolutionarily conserved cytokine TGF-β critically supports a functional T cell pool. The pleiotropic nature of this regulation is likely due to the elaborate control of TGF-β production and activation in the immune system, and the intricacy of TGF-β signaling pathways. In this review we discuss the current understanding of TGF-β regulation of T cells.

[PubMed - indexed for MEDLINE]
[Available on 2014/10/15]
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