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Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women.
Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.
PMID: 2409603 [PubMed - indexed for MEDLINE]
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Cited by 16 PubMed Central articles
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Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy.
Hart TC, Gorry MC, Hart PS, Woodard AS, Shihabi Z, Sandhu J, Shirts B, Xu L, Zhu H, Barmada MM, et al.
J Med Genet. 2002 Dec; 39(12):882-92.
[J Med Genet. 2002]
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ReviewCytokines in asthma.
Chung KF, Barnes PJ.
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[Thorax. 1999]
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A 92-kDa human immunostimulatory protein.
Fontan E, Briend E, Saklani-Jusforgues H, d'Alayer J, Vandekerckhove J, Fauve RM.
Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8353-7.
[Proc Natl Acad Sci U S A. 1994]
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