Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Pediatr Otorhinolaryngol. 2013 Nov;77(11):1846-51. doi: 10.1016/j.ijporl.2013.08.025. Epub 2013 Sep 17.

C-type lectin receptors mRNA expression in patients with otitis media with effusion.

Author information

  • 1Physical Medicine and Rehabilitation, School of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Abstract

OBJECTIVE:

The role of C-type lectin receptor, a type of pattern recognition receptor, in otitis media with effusion (OME) is unclear. We assayed the levels of expression of C-type lectin receptor mRNA in children with OME and evaluated its relationship to the presence of bacteria, accompanying diseases, and characteristics of exudates.

SUBJECTS AND METHODS:

The study population consisted of 73 children with OME who had undergone ventilating tube insertion. The levels of expression of Dectin-1, MR1, MR2, DC-SIGN, Syk, Card-9, Bcl-10, Malt-1, Src, Dec-205, Galectin-1, Tim-3, Trem-1, and DAP-12 mRNA in middle ear effusion were determined by real-time PCR. The level of expression of each mRNA was correlated with the presence of bacteria, accompanying diseases, and exudates characteristics.

RESULTS:

The levels of expression of C-type lectin receptor mRNAs were not associated with bacterial presence or exudates characteristics (p>0.05 each). Levels of expression, however, were significantly higher in patients with sinusitis, adenoid vegetation or adenoiditis, and allergic rhinitis (p<0.05 each).

CONCLUSIONS:

Levels of expression of C-type lectin receptor mRNA may be associated with the pathogenesis of OME, being significantly higher in patients with than without accompanying sinusitis, adenoid vegetation or adenoiditis, and allergic rhinitis.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Adenoid; Allergic rhinitis; C-type lectin receptors; Otitis media with effusion; Sinusitis

PMID:
24094722
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk