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J Allergy Clin Immunol. 2014 Mar;133(3):767-76.e7. doi: 10.1016/j.jaci.2013.07.048. Epub 2013 Oct 4.

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts.

Author information

  • 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: olena.gruzieva@ki.se.
  • 2Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.
  • 3Sanquin Research, Amsterdam, The Netherlands.
  • 4Centre for Epidemiology, Institute of Population Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.
  • 5ZAUM-Centre for Allergy and Environment, Technical University (TUM)/Helmholtz Center Munich, Munich, Germany.
  • 6Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
  • 7Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology I, Neuherberg, Germany.
  • 8Department of Pediatrics, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
  • 9IUF Leibniz Research Institute for Environmental Medicine at the University of Düsseldorf, Düsseldorff, Germany.
  • 10Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • 11Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  • 12School of Environment and Development (Geography), University of Manchester, Manchester, United Kingdom.
  • 13Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom.
  • 14Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden.
  • 15Marien-Hospital Wesel, Research Institute, Department of Pediatrics, Wesel, Germany.
  • 16Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • 17Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Abstract

BACKGROUND:

Evidence on the long-term effects of air pollution exposure on childhood allergy is limited.

OBJECTIVE:

We investigated the association between air pollution exposure and allergic sensitization to common allergens in children followed prospectively during the first 10 years of life.

METHODS:

Five European birth cohorts participating in the European Study of Cohorts for Air Pollution Effects project were included: BAMSE (Sweden), LISAplus and GINIplus (Germany), MAAS (Great Britain), and PIAMA (The Netherlands). Land-use regression models were applied to assess the individual residential outdoor levels of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5), the mass concentration of particles between 2.5 and 10 μm in size, and levels of particulate matter with an aerodynamic diameter of less than 10 μm (PM10), as well as measurement of the blackness of PM2.5 filters and nitrogen dioxide and nitrogen oxide levels. Blood samples drawn at 4 to 6 years of age, 8 to 10 years of age, or both from more than 6500 children were analyzed for allergen-specific serum IgE against common allergens. Associations were assessed by using multiple logistic regression and subsequent meta-analysis.

RESULTS:

The prevalence of sensitization to any common allergen within the 5 cohorts ranged between 24.1% and 40.4% at the age of 4 to 6 years and between 34.8% and 47.9% at the age of 8 to 10 years. Overall, air pollution exposure was not associated with sensitization to any common allergen, with odds ratios ranging from 0.94 (95% CI, 0.63-1.40) for a 1 × 10(-5) ∙ m(-1) increase in measurement of the blackness of PM2.5 filters to 1.26 (95% CI, 0.90-1.77) for a 5 μg/m(3) increase in PM2.5 exposure at birth address. Further analyses did not provide consistent evidence for a modification of the air pollution effects by sex, family history of atopy, or moving status.

CONCLUSION:

No clear associations between air pollution exposure and development of allergic sensitization in children up to 10 years of age were revealed.

Copyright © 2013 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

KEYWORDS:

Air pollution; European Study of Cohorts for Air Pollution Effects; IgE; children; cohort; meta-analysis; sensitization

PMID:
24094547
[PubMed - indexed for MEDLINE]
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