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Neuron. 2013 Oct 2;80(1):4-6. doi: 10.1016/j.neuron.2013.09.018. Epub 2013 Oct 2.

Acid indigestion in the endosome: linking signaling dysregulation to neurodevelopmental disorders.

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  • 1University of Virginia, Department of Neuroscience, 409 Lane Road, Charlottesville, VA 22908, USA.


The sodium-proton exchanger NHE6 contributes to proper endosomal acidification. NHE6 mutations are also linked to autism-related disorders. In this issue of Neuron, using NHE6-knockout mice, Ouyang et al. (2013) uncover how dysregulation of endosomal pH leads to disturbances in BDNF signaling and neuronal morphogenesis defects.

Copyright © 2013 Elsevier Inc. All rights reserved.

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