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Oncoimmunology. 2013 Aug 1;2(8):e25913. Epub 2013 Jul 31.

Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses.

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  • 1Department of Oncology; Ludwig Cancer Research Center; University of Lausanne; Lausanne, Switzerland.

Abstract

B7-H4 inhibits T-cell activation and is widely expressed by solid neoplasms. We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of tumor-specific T cells. Thus, antibodies targeting the B7-H4 pathways may extend the survival of cancer patients by restoring T cell-mediated antitumor responses.

KEYWORDS:

B7-H4; cell surface expression; immunotherapy; ovarian cancer; recombinant antibodies; targeting

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