Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1990 Mar 2;247(4946):1079-82.

Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

Author information

  • 1Department of Microbiology, University of California, Los Angeles 90024.

Abstract

Oncogenic activation of the proto-oncogene c-abl in human leukemias occurs as a result of the addition of exons from the gene bcr and truncation of the first abl exon. Analysis of tyrosine kinase activity and quantitative measurement of transformation potency in a single-step assay indicate that variation in bcr exon contribution results in a functional difference between p210bcr-abl and p185bcr-abl proteins. Thus, foreign upstream sequences are important in the deregulation of the kinase activity of the abl product, and the extent of deregulation correlates with the pathological effects of the bcr-abl proteins.

PMID:
2408149
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk