Science. 1990 Mar 2;247(4946):1077-9.

Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46.

Source

Department of Biochemistry, Stanford Medical Center, CA 94305.

Abstract

Cold-sensitive mutations in the SPB genes (spb1-spb7) of Saccharomyces cerevisiae suppress the inhibition of translation initiation resulting from deletion of the poly(A)-binding protein gene (PAB1). The SPB4 protein belongs to a family of adenosine triphosphate (ATP)-dependent RNA helicases. The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1. These data suggest that mutations affecting different steps of 60S subunit formation can allow PAB-independent translation, and they indicate that further characterization of the spb mutations could lend insight into the biogenesis of the ribosome.

PMID:: 2408148; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID, Grant Support

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Research Support, U.S. Gov't, P.H.S.

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Substances

Secondary Source ID

GENBANK/X16147

Grant Support

R37 GM 21891/GM/NIGMS NIH HHS/United States

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Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46.

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