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Nat Prod Commun. 2013 Aug;8(8):1127-8.

A new macrolide from a marine-derived fungus Aspergillus sp.

Author information

  • 1Key Laboratory of Marine Bio-resources Sustainable Utilization/RNAM Center for Marine Microbiology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.


A new 16-membered macrolide named aspergillide D (1), along with six known compounds, including two polyketones (2-3) and four alkaloids (4-7), were isolated from the culture broth of a marine-derived fungus Aspergillus sp. SCSGAF 0076. The structure of 1 was elucidated on the basis of NMR and mass spectra. Compound 5 showed an obvious inhibitory effect on influenza virus strains H1N1 and H3N2.

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