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Chemistry. 2013 Sep 27;19(40):13322-7. doi: 10.1002/chem.201302740.

Direct access to highly substituted 1-naphthols through palladium-catalyzed oxidative annulation of benzoylacetates and internal alkynes.

Author information

  • 1Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore), Fax: (+65) 6516-1691.


One for the pot: 1-Naphthols, well-known structural design elements in medicinal chemistry, were readily prepared by means of a one-pot palladium-catalyzed oxidative annulation of readily available benzoylacetates to internal alkynes.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


CH activation; alkynes; annulation; naphthols; palladium

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