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Colloids Surf B Biointerfaces. 2014 Jan 1;113:158-68. doi: 10.1016/j.colsurfb.2013.08.010. Epub 2013 Aug 18.

Micellar nanoparticles loaded with gemcitabine and doxorubicin showed synergistic effect.

Author information

  • 1Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China. Electronic address: liudechun2008@126.com.
  • 2Department of Breast Surgery, The First Affiliated Hospital of the Henan University of Science and Technology, Luoyang, Henan 471003, PR China.

Abstract

Gemcitabine and doxorubicin were separately chemically linked to biodegradable polymers to prepare polymer-gemcitabine and polymer-doxorubicin conjugates. Moreover, the two conjugates can self-assemble into micelles with both gemcitabine and doxorubicin. In this way, the two anticancer drugs were combined. The in vitro MTT assay with these combined drugs showed synergistic effect compared to single use of each drug.

Copyright © 2013 Elsevier B.V. All rights reserved.

KEYWORDS:

Doxorubicin; Drug delivery; Gemcitabine; Micelles; Polymer conjugates

PMID:
24077114
[PubMed - in process]
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