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Am J Orthod Dentofacial Orthop. 2013 Oct;144(4):523-32. doi: 10.1016/j.ajodo.2013.05.010.

Effect of parathyroid hormone on experimental tooth movement in rats.

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  • 1Postgraduate student, State Key Laboratory of Oral Diseases and Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Abstract

INTRODUCTION:

The aim of this study was to investigate the effect of parathyroid hormone injection on experimental tooth movement in rats.

METHODS:

Sixty male Wistar rats were randomly divided into 2 groups. Their maxillary right first molars were moved mesially with nickel-titanium closed-coil springs. The experimental group received daily subcutaneous injections of parathyroid hormone at a dose of 4 μg per 100 g of body weight for 12 days, and the control group received vehicle injections. The results were evaluated by intraoral measurements and by hematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemistry staining.

RESULTS:

The tooth movement and osteoclast numbers were significantly increased in the parathyroid hormone group compared with the control group. The expressions of receptor activator of nuclear factor kappa B ligand and insulin-like growth factor-I were significantly stimulated in the parathyroid hormone group.

CONCLUSIONS:

The data suggest that short-term parathyroid hormone injection might be a potential method for accelerating orthodontic tooth movement by increasing the alveolar bone turnover rate.

Copyright © 2013 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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