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J Hosp Infect. 2013 Nov;85(3):237-9. doi: 10.1016/j.jhin.2013.08.005. Epub 2013 Sep 8.

Laboratory exposure to Brucella melitensis in Denmark: a prospective study.

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  • 1Department of Infectious Diseases, Hvidovre University Hospital, Hvidovre, Denmark. Electronic address: andreas.knudsen@hvh.regionh.dk.


Brucella species are a frequent cause of laboratory-acquired infections. This report describes the handling of a laboratory exposure of 17 laboratory staff members exposed to Brucella melitensis in a large microbiology laboratory in a brucella-non-endemic area. We followed the US Centers for Disease Control and Prevention guidelines, but, of 14 staff members classified as high-risk exposure, none accepted post-exposure prophylaxis. However, in a period of 6 months of follow-up, none of the exposed laboratory workers developed brucellosis and all obtained sera were negative for antibrucella antibodies. We therefore question the value of routine serological follow-up.

Copyright © 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.


Brucella melitensis; Brucellosis; Laboratory exposure; Post-exposure prophylaxis

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