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Comput Methods Programs Biomed. 2013 Dec;112(3):356-66. doi: 10.1016/j.cmpb.2013.07.023. Epub 2013 Sep 23.

Anatomical model-based finite element analysis of the combined cryosurgical and hyperthermic ablation for knee bone tumor.

Author information

  • 1Beijing Key Laboratory of Cryo-Biomedical Engineering & Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China. Electronic address: zzhe@mail.ipc.ac.cn.


This paper is aimed at investigating the capacity of using combined cryosurgical and hyperthermic modality for treating knee bone tumor with complex shape. An anatomical model for human knee was constructed and a three-dimensional (3D) finite element analysis was developed to determine temperature distribution of the tissues subject to single freezing (SF), single heating (SH) and alternate freezing-heating (AFH), respectively. The heat fluxes of the probes wall and the ablation volume are particularly tracked to comparatively evaluate the ablation ability of different probe configurations with varied diameter, number and active working length. As example, an effective conformal treatment strategy via one time's insertion while cyclic freezing-heating using multiple probes is designed for a predefined knee bone tumor ablation. Both SF and SH could create large enough ablation volume, while it is hard for them to perform a conformal treatment on irregular and slender knee tumor. As an alternative, AFH could form a flexible and controlled shape and volume of the ablation by changing the size and number of the probes and adjusting their insertion depth. In addition, a thermal protection method is considered to reduce cryoinjury of the health tissue.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.


Alternate freezing–heating; Anatomical CAD model; Cryosurgery; Hyperthermia; Knee bone tumor

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