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Leuk Res. 2014 Mar;38(3):299-303. doi: 10.1016/j.leukres.2013.08.009. Epub 2013 Sep 6.

Extramedullary chronic lymphocytic leukemia: systematic analysis of cases reported between 1975 and 2012.

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  • 1Department of Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, United States.
  • 2James R. & Helen D. Russell Institute for Research & Innovation, Advocate Lutheran General Hospital, Park Ridge, IL, United States.
  • 3Division of Hematology, Mayo Clinic, Rochester, MN, United States.
  • 4Department of Medicine, Section of Hematology and Oncology, The University of Chicago, Chicago, IL, United States. Electronic address: cnabhan@medicine.bsd.uchicago.edu.


The prognostic significance of extra-medullary chronic lymphocytic leukemia (EM-CLL) is unknown. We conducted a Medline database systematic search analyzing English language articles published between 1975 and 2012 identifying 192 cases. Patients with EM-CLL were more commonly treated than not (p < .001). Skin and central nervous system (CNS) were the most commonly reported sites of organ involvement. Survival after diagnosis of EM-CLL appeared to depend on the site of EM involvement. Prospective evaluation and further studies of EM-CLL are warranted.

Copyright © 2013 Elsevier Ltd. All rights reserved.


CLL; Chronic lymphocytic leukemia; Extra-medullary; Prognosis

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