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Acta Chim Slov. 2012 Sep;59(3):632-40.

Construction of some new bioactive building block of thiazolidines.

Abstract

An efficient route for the synthesis of new series of N-[3-(1H-1,2,3-benzotriazol-1-yl)-propyl]-2-(substituted phenyl)-4-oxo-5-(substituted benzylidene)-1,3-thiazolidine-carboxamide has been devised; compounds 5a-j have been synthesized and characterized by IR, 1H NMR, 13C NMR, FAB-MS and chemical elemental analysis. All final compounds were screened for their antimicrobial activity against some selected bacteria and fungi and antituberculosis study against Mycobacterium tuberculosis and antiinflammatory activity on albino rats.

PMID:
24061320
[PubMed]
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