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Antimicrob Agents Chemother. 2013 Dec;57(12):6372-7. doi: 10.1128/AAC.01444-13. Epub 2013 Sep 23.

Whole-cell screening-based identification of inhibitors against the intraphagosomal survival of Mycobacterium tuberculosis.

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  • 1Department of Biochemistry, University of Delhi South Campus, New Delhi, India.

Abstract

We describe here an efficient strategy that employs whole-cell-based screening and further short listing of the compounds by cytotoxicity- and fluorescence-based intracellular assays, resulting in potential bactericidal hits against the growth of Mycobacterium tuberculosis in broth culture as well as in phagosomes. These compounds also inhibited multidrug-resistant strains of M. tuberculosis but showed no or poor inhibition of nonpathogenic mycobacteria or other bacterial species such as Escherichia coli.

PMID:
24060878
[PubMed - indexed for MEDLINE]
PMCID:
PMC3837871
Free PMC Article
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