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CNS Neurol Disord Drug Targets. 2014 Mar;13(2):259-64.

Insulin-degrading enzyme: a link between Alzheimer's and type 2 diabetes mellitus.

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  • 1Laboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology, CSIRCentral Drug Research Institute, Lucknow, 226 001, UP, India.


Enzymes play a very vital role in maintaining the homeostasis inside the body. Improper functioning of enzymes is associated with many diseases. Insulin-degrading enzyme (IDE), a ubiquitously expressed zinc metalloprotease, is believed to act as a junction point of Type 2 Diabetes and Alzheimer's disease. Recent studies provide inkling for the use of IDE as a potential target hence the design of its regulators would be a viable approach towards treatment of these diseases. This review provides an overview of the IDE structure and function; a relationship is drawn between IDE, Type 2 Diabetes mellitus and Alzheimer's disease and the approaches that make IDE a potential target, are discussed.

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