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Immunity. 2013 Sep 19;39(3):423-5. doi: 10.1016/j.immuni.2013.08.023.

Removing the TREX1 safety net: oxidized DNA overcomes immune silencing by exonuclease TREX1.

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  • 1School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: agbowie@tcd.ie.


If DNA accumulates in the cytosol, it activates innate immunity via recently described DNA sensors. In this issue of Immunity, Gehrke et al. (2013) show that oxidized DNA is resistant to degradation by TREX1 and thus has heightened immunostimulatory capacity.

Copyright © 2013 Elsevier Inc. All rights reserved.

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