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J Neuroimmunol. 2013 Nov 15;264(1-2):24-34. doi: 10.1016/j.jneuroim.2013.08.014. Epub 2013 Sep 1.

Differential brain and spinal cord cytokine and BDNF levels in experimental autoimmune encephalomyelitis are modulated by prior and regular exercise.

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  • 1Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil; Programa de Pós Graduação em Ciências Biológicas: Fisiologia-Farmacologia, CAPES Foundation, Ministry of Education of Brazil, Brasília, DF 70040-020, Brazil.


The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated. In the exercised EAE mice, although there was no effect on infiltrated cells, the cytokine and derived neurotrophic factor (BDNF) levels were altered, and the clinical score was attenuated. Although, the cytokine levels were decreased in the brain and increased in the spinal cord, BDNF was elevated in both compartments with a tendency of lesser demyelization volume in the spinal cord of the exercised EAE group compared with the unexercised.

© 2013.


BDNF; Exercise; Experimental autoimmune encephalomyelitis; Intravital microscopy; Neuroinflammation; Neuroprotection

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