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Biochemistry. 2013 Oct 15;52(41):7170-83. doi: 10.1021/bi400597v. Epub 2013 Oct 1.

Single-molecule dynamics and mechanisms of metalloregulators and metallochaperones.

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  • 1Department of Chemistry and Chemical Biology, Cornell University , Ithaca, New York 14853, United States.

Abstract

Understanding how cells regulate and transport metal ions is an important goal in the field of bioinorganic chemistry, a frontier research area that resides at the interface of chemistry and biology. This Current Topic reviews recent advances from the authors' group in using single-molecule fluorescence imaging techniques to identify the mechanisms of metal homeostatic proteins, including metalloregulators and metallochaperones. It emphasizes the novel mechanistic insights into how dynamic protein-DNA and protein-protein interactions offer efficient pathways via which MerR-family metalloregulators and copper chaperones can fulfill their functions. This work also summarizes other related single-molecule studies of bioinorganic systems and provides an outlook toward single-molecule imaging of metalloprotein functions in living cells.

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