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J Anesth. 2014 Apr;28(2):228-34. doi: 10.1007/s00540-013-1708-3. Epub 2013 Sep 19.

Antinociceptive effect of intracerebroventricular administration of D-serine on formalin-induced pain.

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  • 1Department of Anesthesiology, Tokai University School of Medicine, Isehara, Kanagawa, 259-1193, Japan, maedamih@is.icc.u-tokai.ac.jp.

Abstract

PURPOSE:

In a previous study using the tail-flick test, we found that intracerebroventricular administration of D-serine, an endogenous co-agonist at the glycine sites of N-methyl-D-aspartate (NMDA) receptors, elicited an antinociceptive effect on thermal nociception. The purpose of the present study was to evaluate the effect of intracerebroventricular administration of D-serine on nociception induced by tissue damage or inflammation using the formalin test.

METHODS:

Infusion of drugs into the third ventricle in rat was performed via indwelling cannulae. Drugs were infused at a volume of 10 μl over 2 min, and the infusion cannula was left in place for 2 min before removal. The formalin test was performed 10 min after drug administration.

RESULTS:

Intracerebroventricular administration of D-serine significantly and dose-dependently decreased the number of flinches in both the early and late phases in the formalin test. This antinociceptive effect was antagonized by intracerebroventricular administration of L-701,324, a selective antagonist at the glycine sites of NMDA receptors.

CONCLUSION:

The present data suggest that activation of NMDA receptors via glycine sites at the supraspinal level induces an antinociceptive effect on both acute and tonic pain.

PMID:
24048610
[PubMed - indexed for MEDLINE]
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