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Curr Opin Rheumatol. 2013 Nov;25(6):772-7. doi: 10.1097/01.bor.0000434664.37880.ac.

The diagnostic utility of autoantibodies in adult and juvenile myositis.

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  • 1aRoyal National Hospital for Rheumatic Diseases bUniversity of Bath, Bath, UK.

Abstract

PURPOSE OF REVIEW:

The purpose of this study is to review recent advances in the diagnostic utility of autoantibodies in dermatomyositis.

RECENT FINDINGS:

Alternative nonspecialist testing methods have been developed for anti-transcription intermediary factor 1 gamma, anti-MDA5 and anti-nuclear matrix protein 2, which are potentially exploitable by any hospital laboratory. Although these have yet to be validated for diagnostic use, it is likely that testing for myositis-specific antibodies will soon become readily available.

SUMMARY:

The identification of myositis-specific autoantibodies provides both diagnostic and prognostic information and offers a unique opportunity to adopt a stratified approach to treatment. Their identification, in many cases, should prevent the need for invasive diagnostic tests such as muscle biopsy.

[PubMed - indexed for MEDLINE]
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