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Cardiol Young. 2014 Oct;24(5):900-4. doi: 10.1017/S1047951113001376. Epub 2013 Sep 18.

Initial use of endothelial progenitor cells capturing stents in paediatric congenital heart disease.

Author information

  • 11Department of Cardiology,Santarém Hospital,Santarém,Portugal.
  • 22Department of Pediatric Cardiology,Santa Marta Hospital,Central Lisbon Hospital Center,Lisbon,Portugal.

Abstract

INTRODUCTION:

Stenosis, mediated by neointimal hyperplasia and thrombosis, is a major limiting factor in successful stent implantation. The introduction of a stent, coated in its endoluminal surface by antihuman CD34 antibodies with endothelial progenitor cell-capturing properties, opens the possibility of promoting a rapid and normal functioning coverage by endothelium and thus avoids both an excessive cell proliferation within stent and the need for long-term dual antiplatelet therapy. These stents, developed for adult coronary artery disease, have not yet been implanted in children or in those with congenital heart disease.

OBJECTIVE AND METHODS:

In this paper, we describe the implantation of Genous® stents in three children with cyanotic congenital heart disease and obstructed systemic-to-pulmonary shunts. We describe the use of this stent and address its potential feasibility in paediatric congenital heart disease.

RESULTS:

To maintain the patency of two modified Blalock-Taussig shunts and one ductus arteriosus, four Genous® stents were implanted in three infants with cyanotic heart disease. All procedures were immediately successful, with resolution of stenosis and improvement in transcutaneous oxygen saturation from 66% ± 3.6% to 92% ± 2.6%. In the follow-up, one stent had no occlusion; however, the remaining two had partial occlusion after 5 and 5.5 months, which were successfully managed with balloon dilatation preceding elective definitive surgical correction.

CONCLUSION:

In our preliminary experience, we demonstrated that Genous® stent implantation was feasible in infants with complex congenital heart disease. Additional studies with larger samples and longer follow-up are required to confirm the potential benefits of this technology in this clinical setting.

PMID:
24044550
[PubMed - indexed for MEDLINE]
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