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World J Mens Health. 2013 Aug;31(2):141-9. doi: 10.5534/wjmh.2013.31.2.141. Epub 2013 Aug 31.

Effects of sesame oil on the reproductive parameters of diabetes mellitus-induced male rats.

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  • 1Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Abstract

PURPOSE:

The purpose of the present study was to investigate the effect of sesame oil on the reproductive parameters of diabetic male Wistar rats.

MATERIALS AND METHODS:

The adult male rats in a split plot design were divided into normal (n=10), normal 5% (n=5; 5% sesame oil enriched diet), diabetic (Streptozocin induced diabetes; n=9), diabetic 5% (n=9; 5% sesame oil enriched diet), and diabetic 10% (n=9; 10% sesame oil enriched diet) groups. Diet supplementation continued for 56 days.

RESULTS:

Sesame oil supplementation did not reduce the plasma glucose concentration of rats in the diabetic groups (p>0.05). The total spermatogonia, spermatocytes, Leydig cells/tubule, and the germ cell to Sertoli cell ratio were lower in the diabetic rats than the normal ones (p<0.05), and with the exception of spermatogonia counts, these values improved by the addition of sesame oil to the diet (p<0.05). The sperm progressive motility and viability were lower in the diabetic rats (p<0.05) and sesame oil supplementation did not improve them. Incorporation of sesame oil into the diet improved the plasma testosterone concentration of the diabetic rats in a dose-dependent manner (p<0.05).

CONCLUSIONS:

In summary, sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function, but was not effective in protecting the epididymal sperm.

KEYWORDS:

Diabetes mellitus; Rats; Sesame oil; Spermatozoa; Testis; Testosterone

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