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Bull Environ Contam Toxicol. 2013 Nov;91(5):583-7. doi: 10.1007/s00128-013-1103-7. Epub 2013 Sep 17.

Mutagenicity and genotoxicity in gill erythrocyte cells of Poecilia reticulata exposed to a glyphosate formulation.

Author information

  • 1Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brasília, DF, CEP 70919-970, Brazil.

Abstract

Poecilia reticulata were exposed to herbicide Roundup Transorb(®) for micronucleus test, nuclear abnormalities and comet assay. The exposure-concentrations were based on CL50-96 h following 0, 1.41, 2.83, 4.24 and 5.65 μL L(-1) for 24 h. Micronucleus and comets were significantly increased in the gill erythrocyte cells after herbicide exposure compared with the non-exposed group. Results showed a gradual increase in the number of damaged cells, indicating a concentration-dependent effect and that this herbicide was mutagenic and genotoxic to P. reticulata and this effect could be attributed to a combination of compounds contained in the formulation with the active ingredient glyphosate.

PMID:
24042842
[PubMed - indexed for MEDLINE]
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