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Cancer Lett. 2013 Sep 14. pii: S0304-3835(13)00662-9. doi: 10.1016/j.canlet.2013.09.009. [Epub ahead of print]

Non-targeted effects induced by ionizing radiation: Mechanisms and potential impact on radiation induced health effects.

Author information

  • 1Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, United States. Electronic address: wfmorgan@pnnl.gov.

Abstract

Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1Gy), at low doses (<100mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Cell-cell communication; Ionizing radiation; Non-targeted effects

PMID:
24041870
[PubMed - as supplied by publisher]
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