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Bioorg Med Chem Lett. 2013 Nov 1;23(21):6010-4. doi: 10.1016/j.bmcl.2013.08.004. Epub 2013 Aug 9.

Anti-inflammatory constituents from the fruits of Vitex rotundifolia.

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  • 1College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.

Abstract

Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5μM.

Copyright © 2013 Elsevier Ltd. All rights reserved.

KEYWORDS:

Diterpene; Neolignan; Nitric oxide; Verbenaceae; Vitex rotundifolia

[PubMed - indexed for MEDLINE]
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