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Nutrition. 2013 Nov-Dec;29(11-12):1331-5. doi: 10.1016/j.nut.2013.04.013. Epub 2013 Sep 12.

Cardiometabolic factors and disease duration in patients with Parkinson's disease.

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  • 1Parkinson Institute-Istituti Clinici di Perfezionamento, Milano, Italy.

Abstract

OBJECTIVE:

Previous studies have reported that patients with Parkinson's disease (PD) have a favorable cardiometabolic risk profile. The aim of this study was to investigate the relationship between cardiometabolic risk factors and the duration of disease.

METHODS:

One hundred and fifty patients with PD (56.7% men) were studied, measuring body mass index (BMI), waist circumference (WC), body fat percentage (BF%) by impedance, fasting glucose, serum lipids, and transaminases.

RESULTS:

In sex- and age-adjusted correlation models, duration of PD was inversely related to BMI (r = -0.20; P < 0.05) and BF% (r = -0.29; P < 0.005). Using multivariable regression models (adjustments: age, gender, smoking status, levodopa dose and, alternatively, BMI, WC, or BF%), high-density lipoprotein (HDL) levels were positively correlated with disease duration (P < 0.01 for all). In models adjusted for WC and BF%, total HDL-cholesterol ratio was also inversely associated with duration of PD (P < 0.05 for both). No other association between biochemical variables and the duration of PD was found. Moreover, no dose-response effect of levodopa on metabolic risk factors was observed.

CONCLUSIONS:

HDL levels and total HDL-cholesterol ratio were favorably associated with duration of PD. This factor may contribute to cardiometabolic protection in PD. The mechanisms underlying this association deserve further investigation.

Copyright © 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

Adiposity; Cardiometabolic risk factors; Disease duration; Nutritional status; Parkinson’s disease

PMID:
24035054
[PubMed - indexed for MEDLINE]
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