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Brain Pathol. 2014 Mar;24(2):166-72. doi: 10.1111/bpa.12089. Epub 2013 Nov 27.

Post-chemotherapy maturation in supratentorial primitive neuroectodermal tumors.

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  • 1Division of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, Calgary, Alberta, Canada.


Maturation in central nervous system embryonal tumors is an uncommon phenomenon that is mainly reported in the context of specific histological subgroups of medulloblastoma. In this report we describe two cases of histological maturation in patients with supratentorial primitive neuroectodermal tumor with strikingly different outcomes. We discuss the potential impact of such findings on treatment and outcome.

© 2013 International Society of Neuropathology.


ETANTR; ETMR; maturation; prognosis; sPNET

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