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Br J Haematol. 2013 Dec;163(5):640-5. doi: 10.1111/bjh.12560. Epub 2013 Sep 13.

Changes in angiogenesis and hypoxia-inducible factor-1α protein expression in relapsed/refractory indolent non-Hodgkin lymphomas.

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  • 1Haematology Unit, Department of Medical and Experimetal Oncology, IRCCS National Cancer Research Centre "Giovanni Paolo II", Bari, Italy.


Angiogenesis is involved in the pathogenesis and progression of non-Hodgkin lymphomas (NHL), and hypoxia-inducible factor-1α (HIF-1α, also termed HIF1A) might contribute to this process. Currently, there is no direct evidence that the clinical progression of indolent NHL is associated with angiogenesis, and the expression of HIF-1α at recurrence is unknown. Matched lymph node biopsies at diagnosis and recurrence of relapsed/refractory indolent NHL patients were analysed by immunohistochemical and morphometric analysis. We observed an increased vascular network and HIF-1α protein expression in the second biopsy, providing direct evidence that angiogenesis is an essential process for disease progression.

© 2013 John Wiley & Sons Ltd.


angiogenesis; hypoxia-inducible factor-1α; indolent non-Hodgkin lymphomas; pathogenesis; relapse/progression

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