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Angew Chem Int Ed Engl. 2013 Sep 16;52(38):9976-9. doi: 10.1002/anie.201303370. Epub 2013 Sep 3.

A synthetic riboswitch that operates using a rationally designed ligand-RNA pair.

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  • 1The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); PRESTO (Japan) Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012 (Japan).


The construction of an artificial riboswitch is based on a ligand-RNA pair without any molecular biology-based selection processes. The ligand selectively and significantly stabilized an RNA duplex containing an r(XGG)/r(XGG) sequence (X=U, A, G). The integration of the ligand-binding sequences into the 5'-untranslated region of mRNA provided an artificial riboswitch that was responsive to Z-NCTS.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


RNA-binding ligand; naphthyridine; riboswitches; synthetic ligands; translational regulation

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