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Curr Biol. 2013 Sep 9;23(17):R741-5. doi: 10.1016/j.cub.2013.08.011.

The biochemistry of memory.

Author information

  • 1Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA. Electronic address: jstock@princeton.edu.

Abstract

Almost fifty years ago, Julius Adler initiated a program of research to gain insights into the basic biochemistry of intelligent behavior by studying the molecular mechanisms that underlie the chemotactic responses of Escherichia coli. All living organisms share elements of a common biochemistry for metabolism, growth and heredity - why not intelligence? Neurobiologists have demonstrated that this is the case for nervous systems in animals ranging from worms to man. Motile unicellular organisms such as E. coli exhibit rudimentary behaviors that can be loosely described in terms of cognitive phenomena such as memory and learning. Adler's initiative at least raised the prospect that, because of the numerous experimental advantages provided by E. coli, it would be the first organism whose behavior could be understood at molecular resolution.

Copyright © 2013 Elsevier Ltd. All rights reserved.

PMID:
24028956
[PubMed - indexed for MEDLINE]
PMCID:
PMC3971467
Free PMC Article

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