Send to:

Choose Destination
See comment in PubMed Commons below
Anticancer Res. 2013 Sep;33(9):4111-5.

Anal carcinoma: surgery does not influence prognosis when performed prior to concurrent radiochemotherapy.

Author information

  • 1Department for Radiation Oncology, Charité School of Medicine and University Hospital Berlin, Augustenburger Platz 1, 13353 Berlin, Germany,



Concurrent radiochemotherapy (cRCT) is the standard-of-care for patients with locally advanced anal cancer. There is a subgroup of patients however, vastly with small tumors, which undergo local excision before combined modality treatment. It was suggested that local excision prior to cRCT might improve the local control in comparison with cRCT. We evaluated local excision in comparison to incisional biopsy in this setting.


Between 2000 and 2005, 84 patients were included in the study. In the majority of patients, only incisional biopsy (INC) was performed for the histopathological verification. Other patients underwent surgery prior to the RCT course as excisional biopsy (EXC). The chemotherapy consisted of 5-fluorouracil (800/1000 mg/m(2)/d, 4 consecutive days, w 1, five) and mitomycin C (2 times 10 mg/m(2)). Radiotherapy was prescribed 45 at Gy.


All patients (T1-2) were available for analysis. 14% of patients had node-positive disease. For the entire series, at five years and eight years, the actuarial OAS rates were 71% and 54%, respectively; the DSS rates were 74% and 68%, respectively; and the DFS rates were 54% and 54%, respectively. The actuarial control rate achieved by the EXC group was 80% after five years, better than the one for the INC group at 64%. Univariate analysis showed that tumor stage T3-T4 (p=0.04), tumor size ≥6 cm (p<0.001), nodal stage N1-3 (p<0.00) and OTT >40 days (p=0.05) are significantly correlated with poorer local disease control. Local excision in comparison with INC did not prove to be significant for local disease control (p=0.45). No significance was found for pre-therapeutic prognostic factors age, gender, histological type and grading. Multivariate analysis showed that tumor size as continuous variable (p=0.02) and OTT (p=0.04) remained significant when adjusted for T-stage and nodal stage.


According to this highly qualitative trial, surgical excision prior to cRCT, did not improve results. cRCT was confirmed as the standard-of-care.


Anal carcinoma; local control; prognosis; radiochemotherapy

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk