Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Microbiol. 2013 Aug;11(8):587-91.

A problem of persistence: still more questions than answers?

Author information

  • 1The Racah Institute of Physics, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. nathalieqb@phys.huji.ac.il

Abstract

The current antibiotic resistance crisis has led to increased pressure to prioritize strategies to tackle the issue, with a strong focus being placed on the development of novel antimicrobials. However, one major obstacle that is often overlooked is persister cells, which are refractory to antibiotic treatment. Tackling persistence is a challenge because these cell types are extremely difficult to study and, consequently, little is known about their physiology and the factors that lead to their emergence. Here, four experts contemplate the main physiological features that define persistence and the implications of persistence for antibiotic treatment regimens, and consider what the study of bacterial persistence has taught us about the heterogeneity of bacterial populations.

Comment in

PMID:
24020075
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk