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Cancer Discov. 2013 Sep;3(9):975-7. doi: 10.1158/2159-8290.CD-13-0427.

Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools?

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  • 1The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

In this issue of Cancer Discovery, Witherspoon and colleagues use an unbiased metabolite profiling approach to study the effects of polyamine depletion by 2-difluoromethylornithine in colon cancer cells. Their surprising findings indicate that it is a decrease in thymidine pools resulting from altered tetrahydrofolate availability rather than decreases in polyamines that produces cytostasis.

©2013 AACR.

PMID:
24019331
[PubMed - indexed for MEDLINE]
PMCID:
PMC3786367
Free PMC Article
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