Format

Send to:

Choose Destination
See comment in PubMed Commons below
Exp Neurol. 2013 Nov;249:160-8. doi: 10.1016/j.expneurol.2013.08.017. Epub 2013 Sep 5.

Antidepressant effects after short-term and chronic stimulation of the subgenual cingulate gyrus in treatment-resistant depression.

Author information

  • 1Department of Psychiatry, Charité - Universitätsmedizin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany; Dahlem Institute for Neuroimaging of Emotion, Freie Universität Berlin, Habelschwerdter Allee 45, 14195 Berlin, Germany; Department of Neurology, Charité - Universitätsmedizin, Campus Virchow, Augustenburger Platz 1, 13353 Berlin, Germany. Electronic address: angela.merkl@charite.de.

Abstract

BACKGROUND:

Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an experimental approach in treatment-resistant depression (TRD). Apart from its potential long-term antidepressant effects acute stimulation effects have been described. We investigated putative neuroanatomical clusters in which such acute effects accumulate and followed patients over the long-term.

METHODS:

We assessed safety and efficacy of DBS in six patients with TRD receiving bilateral DBS with electrodes implanted in the SCG. First, high intensity 130 Hz stimulation was applied on five consecutive days after surgery for 24 h comprising a sham condition in a double-blind, randomized design. Acute stimulation was conducted at all four homologous electrode contacts on both sides. Afterwards, chronic stimulation was initiated and the clinical effect was evaluated at 24-36 weeks compared to baseline (50% reduction in HAMD scores). The primary outcome criterion was depression severity as assessed with the Hamilton Depression Rating Scale (HAMD-24); secondary outcome parameters were the Montgomery-Åsberg Rating-Scale and Beck Depression Inventory following DBS. The clinical effect over the three scores was compared to sham stimulation and was correlated to the anatomical localization of active contacts by stereotactically delimiting the cluster of most effective contacts in responding patients.

RESULTS:

Acute 24 h of stimulation showed only moderate reductions in mean HAMD-24, MADRS and BDI scores. At the last observation (24-36 weeks), two patients were remitters (HAMD-24 < 10) and the four other patients were non-responders.

CONCLUSIONS:

Our results confirm that stimulation of the SCG is capable of exerting moderate acute and chronic antidepressant effects. The predictive value of these findings needs to be addressed in future studies.

© 2013.

KEYWORDS:

Affective disorders; Anterior subgenual cingulate gyrus; Cg25; Deep brain stimulation; Depression; Treatment-resistant

PMID:
24012926
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk