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Diagn Interv Imaging. 2014 Jan;95(1):55-62. doi: 10.1016/j.diii.2013.07.008. Epub 2013 Sep 4.

PET-CT and diagnostic CT: the synergy of metabolic and morphological data in onco-haematology.

Author information

  • 1University of Lyon, Faculty of Medicine, EA 3738, UCB Lyon 1, Lyon, France; Hospices Civils de Lyon, Lyon South General Hospital, Nuclear Medicine and Radiology Department, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France. Electronic address: fabienricard@aliceadsl.fr.
  • 2University of Lyon, Faculty of Medicine, EA 3738, UCB Lyon 1, Lyon, France; Hospices Civils de Lyon, Lyon South General Hospital, Nuclear Medicine and Radiology Department, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France.
  • 3Hospices Civils de Lyon, Lyon South General Hospital, Nuclear Medicine and Radiology Department, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France.
  • 4University of Lyon 1, 69003 Lyon, France; University of Lyon, EA santé-individu-société, 69003 Lyon, France; Hospices Civils de Lyon, IMER Unit, 162, avenue Lacassagne, 69003 Lyon, France.
  • 5Hospices Civils de Lyon, Lyon South General Hospital, Haematology Department, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France.
  • 6University of Lyon 1, 69003 Lyon, France; Hospices Civils de Lyon, Lyon South General Hospital, Haematology Department, 165, chemin du Grand-Revoyet, 69495 Pierre-Bénite cedex, France.

Abstract

PURPOSE:

Our goal was to determine how interpreting diagnostic CT together with PET-CT could improve the assessment of morphology in onco-haematology.

PATIENTS AND METHODS:

Fifty-nine patients with aggressive lymphoma were retrospectively included. The diagnostic CT scan was interpreted by two radiologists, followed by a combined analysis of the CT and the PET-CT carried out by two specialists in metabolic and morphological imaging. The diagnostic performances were assessed in terms of sensitivity and specificity, then concordance and discordance rates (kappa) were studied.

RESULTS:

A combined interpretation of CT and PET-CT showed better diagnostic performances than those of interpretations of CT only in the assessment of nodal sites (826 sites, sensitivity of 99% versus 85%, P<0.05), extranodal sites (649 sites, sensitivity of 88% versus 78%) and bone sites (one analysed per patient, sensitivity of 50% versus 27%). The combined interpretation also improved inter-observer agreement and led to an upgraded Ann Arbor staging in 15% of patients, with a change of treatment in 10%.

CONCLUSION:

Interpretation of diagnostic CT in onco-haematology can be improved by combining it with an assessment of PET-CT. The synergy between metabolic and morphological information leads to improved diagnostic capabilities and renders interpretations more reproducible.

Copyright © 2013 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

KEYWORDS:

CT; Haematology; Lymphoma; Positron emission tomography

PMID:
24012287
[PubMed - in process]
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