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Semin Nephrol. 2013 Jul;33(4):327-40. doi: 10.1016/j.semnephrol.2013.05.005.

Epigenetic alterations in acute kidney injury.

Author information

  • 1University of Washington Medicine Lake Union, Department of Medicine, University of Washington, Seattle, WA. Electronic address: karolb@u.washington.edu.

Abstract

Acute kidney injury (AKI) is a risk factor for chronic kidney disease and death. Despite progress made in understanding the cellular and molecular basis of AKI pathogenesis there has been no improvement in the high mortality rate from this disease in decades. Epigenetics is one of the most intensively studied fields of biology today and represents a new paradigm for understanding the pathophysiology of disease. Although epigenetics of AKI is a nascent field, the available information already is providing compelling evidence that chromatin biology plays a critical role in this disease. In this article we explore what is known about the contribution of epigenetic mechanisms to the pathophysiology of AKI and how this knowledge already is guiding the development of new diagnostic tools and epigenetic therapies.

© 2013 Elsevier Inc. All rights reserved.

KEYWORDS:

DNA methylation; Epigenetics; acute kidney injury; chromatin; histone modification

PMID:
24011575
[PubMed - indexed for MEDLINE]
PMCID:
PMC3768006
Free PMC Article
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