Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Gastroenterol Hepatol Nutr. 2012 Dec;15(4):272-5. doi: 10.5223/pghn.2012.15.4.272. Epub 2012 Dec 31.

Acute Pancreatitis Induced by Azathioprine and 6-mercaptopurine Proven by Single and Low Dose Challenge Testing in a Child with Crohn Disease.

Author information

  • 1Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea.


We report here a case of drug-induced acute pancreatitis proved by elimination and single, low dose challenge test in a child with Crohn disease. A 14-year-old boy with moderate/severe Crohn disease was admitted due to high fever and severe epigastric pain during administration of mesalazine and azathioprine. Blood test and abdominal ultrasonography revealed acute pancreatitis. After discontinuance of the medication and supportive care, the symptoms and laboratory findings improved. A single, low dose challenge test was done to confirm the relationship of the adverse drug reaction and acute pancreatitis, and to discriminate the responsible drug. Azathioprine and 6-mercaptopurine showed positive responses, and mesalazine showed a negative response. We introduce the method of single, low dose challenge test and its interpretation for drug-induced pancreatitis.


6-mercaptopurine; Acute pancreatitis; Azathioprine; Child; Crohn disease; Inflammatory bowel diseases; Mesalamine

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition Icon for PubMed Central
    Loading ...
    Write to the Help Desk