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Chem Commun (Camb). 2013 Oct 14;49(80):9131-3. doi: 10.1039/c3cc45231j. Epub 2013 Sep 4.

Monosubstituted alkenyl amino acids for peptide "stapling".

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  • 1School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.


Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.

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