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Chem Commun (Camb). 2013 Oct 14;49(80):9131-3. doi: 10.1039/c3cc45231j. Epub 2013 Sep 4.

Monosubstituted alkenyl amino acids for peptide "stapling".

Author information

  • 1School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK. A.J.Wilson@leeds.ac.uk.

Abstract

Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.

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