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J Control Release. 2013 Nov 28;172(1):281-91. doi: 10.1016/j.jconrel.2013.08.022. Epub 2013 Sep 1.

Spatial-temporal event adaptive characteristics of nanocarrier drug delivery in cancer therapy.

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  • 1Biochemistry and biomaterial key laboratory of Shandong colleges and universities, College of Marine Life Science, Ocean University of China, Yushan Road, Qingdao, Shandong Province 266003, China. Electronic address: kongming@ouc.edu.cn.


In cancer therapy, drug delivery is a complex process that aims to transit the cargo to the destination with as little damage to the normal tissue as possible. In the last decade, tremendous development and research on nanomedicine have been exploring an ideal system with efficient drug transportation and release property. For this end, series of barriers need to be circumvented by nanomedicine, including systemic barriers, such as biosurface adsorption, phagocytic clearance, bloodstream washing, interstitial pressure, degradation, as well as intracellular barriers, such as cell membrane reorganization and internalization, endo/lysosomal escape, cytosolic or subcellular localization. Rather than being random, these barriers follow a specific spatial-temporal sequence. Therefore, the nanocarriers have to be endowed with characteristics that are adaptive to particular biological milieu on systemic and intracellular levels. To this end, we reviewed the correlations between the spatial-temporal sequences of drug delivery and nanocarrier characteristics in cancer therapy, as well as strategies to achieve efficient drug delivery upon both systemic and intracellular levels.

© 2013.


Drug delivery; Intracellular targeting; Spatial–temporal sequence; Stimuli-responsive; Systemic targeting

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