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Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15431-6. doi: 10.1073/pnas.1308816110. Epub 2013 Sep 3.

Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila.

Author information

  • 1Department of Cellular Biology and Biomedical and Health Sciences Institute, University of Georgia, Athens, GA 30602.

Abstract

The easy accessibility of energy-rich palatable food makes it difficult to resist food temptation. Drosophila larvae are surrounded by sugar-rich food most of their lives, raising the question of how these animals modulate food-seeking behaviors in tune with physiological needs. Here we describe a circuit mechanism defined by neurons expressing tdc2-Gal4 (a tyrosine decarboxylase 2 promoter-directed driver) that selectively drives a distinct foraging strategy in food-deprived larvae. Stimulation of this otherwise functionally latent circuit in tdc2-Gal4 neurons was sufficient to induce exuberant feeding of liquid food in fed animals, whereas targeted lesions in a small subset of tdc2-Gal4 neurons in the subesophageal ganglion blocked hunger-driven increases in the feeding response. Furthermore, regulation of feeding rate enhancement by tdc2-Gal4 neurons requires a novel signaling mechanism involving the VEGF2-like receptor, octopamine, and its receptor. Our findings provide fresh insight for the neurobiology and evolution of appetitive motivation.

KEYWORDS:

PDGF/VEGF receptor (Pvr); Ras; downstream of receptor kinase (Drk); feeding behavior

PMID:
24003139
[PubMed - indexed for MEDLINE]
PMCID:
PMC3780881
Free PMC Article

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