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Dev Psychobiol. 2014 May;56(4):821-35. doi: 10.1002/dev.21155. Epub 2013 Sep 3.

The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age.

Author information

  • 1Department of Pediatrics, Women and Infants Hospital of Rhode Island, Brown Center for the study of Children at Risk; Department of Psychiatry, Warren Alpert Medical School of Brown University. econradt@wihri.org.

Abstract

We employed latent growth curve analysis to examine trajectories of respiratory sinus arrhythmia (RSA) from 3 to 6 years among children with varying levels of prenatal substance exposure and early adversity. Data were drawn from a prospective longitudinal study of prenatal substance exposure that included 1,121 participants. Baseline RSA and RSA reactivity to an attention-demanding task were assessed at 3, 4, 5, and 6 years. Overall, there were significant individual differences in the trajectories of RSA reactivity, but not baseline RSA, across development. Greater levels of prenatal substance exposure, and less exposure to early adversity, were associated with increased RSA reactivity at 3 years, but by 6 years, both were associated with greater RSA reactivity. Prenatal substance exposure had an indirect influence through early adversity on growth in RSA reactivity. Results are in support of and contribute to the framework of allostatic load.

© 2013 Wiley Periodicals, Inc.

KEYWORDS:

allostatic load; early adversity; prenatal substance exposure; respiratory sinus arrhythmia

PMID:
24002807
[PubMed - in process]
PMCID:
PMC4132658
Free PMC Article

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