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Antimicrob Agents Chemother. 2013 Dec;57(12):6341-3. doi: 10.1128/AAC.00963-13. Epub 2013 Sep 3.

Amphotericin B-impregnated bone cement to treat refractory coccidioidal osteomyelitis.

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  • 1Department of Pharmacy, University of California Davis Medical Center, Sacramento, California, USA.

Abstract

Use of amphotericin B-impregnated bone cement in combination with systemic antifungals for the treatment of coccidioidal osteomyelitis offers the potential for sustained local concentrations of drug at the site of the infection. Amphotericin B levels in bone of up to 5.1 μg/g have been demonstrated 4 months after placement of bone cement.

PMID:
24002101
[PubMed - indexed for MEDLINE]
PMCID:
PMC3837876
Free PMC Article
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