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Antimicrob Agents Chemother. 2013 Nov;57(11):5771-3. doi: 10.1128/AAC.00721-13. Epub 2013 Sep 3.

In vitro activities of amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim-sulfamethoxazole against biofilm of Brazilian strains of Burkholderia pseudomallei.

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  • 1Specialized Medical Mycology Center, Federal University of CearĂ¡, Fortaleza, CearĂ¡, Brazil.

Abstract

This study aimed at investigating the in vitro activities of amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim-sulfamethoxazole against Burkholderia pseudomallei in planktonic and biofilm forms, through broth microdilution and resazurin-based viability staining, respectively. In planktonic growth, the strains were susceptible to the drugs, while in biofilm growth, significantly higher antimicrobial concentrations were required, especially for ceftazidime and imipenem, surpassing the resistance breakpoints. These results highlight the importance of the routine evaluation of biofilm antimicrobial susceptibility.

PMID:
24002089
[PubMed - indexed for MEDLINE]
PMCID:
PMC3811307
Free PMC Article
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