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Mult Scler. 2014 Feb;20(2):165-73. doi: 10.1177/1352458513494489. Epub 2013 Sep 2.

Cytomegalovirus seropositivity is negatively associated with multiple sclerosis.

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  • 1Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Solna, Sweden.

Abstract

BACKGROUND:

Epidemiological data suggest a role for common viruses in the pathogenesis of multiple sclerosis (MS), and recent data showed a negative association of past cytomegalovirus (CMV) infection on pediatric MS risk.

OBJECTIVE:

Our aim was to analyze the association of CMV infection with MS risk in an adult case-control material. A meta-analysis was performed to validate our findings.

METHODS:

Epidemiological Investigation in MS (EIMS) is a case-control study with incident cases and population-based controls. Anti-CMV antibody titers were measured with ELISA, and HLA-A and DRB1 genotyping was performed with SSP-PCR, in 658 MS cases, who all fulfilled the McDonald criteria for MS, and 786 controls.

RESULTS:

CMV seropositivity was associated with a decreased MS risk, OR = 0.73 (0.58-0.92 95% CI), p = 0.005, adjusted for index age, gender, smoking, sun exposure, EBNA1 IgG titer and HLA-A*02 and DRB1*15. When we removed all cases and controls younger than 18 years at index, the protective effect was still apparent.

CONCLUSIONS:

CMV is negatively associated with adult-onset MS pathology, consistent with results from a study on pediatric MS cases. It remains to be shown whether this negative association is due to a true protective effect of CMV infection on MS risk.

KEYWORDS:

Multiple sclerosis; case-control study; cytomegalovirus; environmental factors; viral infections

PMID:
23999606
[PubMed - indexed for MEDLINE]
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